“The Long Signal”
Signals the pituitary to release its own GH. The no-DAC version is dosed multiple times daily and mimics natural pulses; the DAC version lasts much longer but is the higher-risk variant.
CJC-1295 is a GHRH analogue, mimicking the natural hormone that tells your pituitary to release GH. The no-DAC version clears quickly and mimics natural pulses; adding DAC (a fatty acid chain) makes it bind to blood proteins and last for days instead of minutes.
No-DAC clears in about 30 minutes and needs multiple daily doses to mimic natural GH pulses. DAC extends that to several days, which raises average GH levels more continuously, and is generally considered the higher-risk variant.
It's not FDA-approved for human use and is sold as a research chemical only.
It's commonly discussed alongside Ipamorelin, since a GHRH analogue and a GHRP work on different parts of the same pathway.
CJC-1295 has a reasonable body of human research behind the GHRH mechanism itself, though most of that comes from academic study of the no-DAC form. The DAC variant is less studied and carries more theoretical risk from sustained hormone elevation.
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